No. Universe will connect to only one database.
How do you define universe parameters?
The first step in creating a universe is to specify its parameters. These parameters include the definition of a universe, which is comprised of: the universe name, a description of the universe, a connection to an RDBMS. You enter universe parameters from the Universe Parameters dialog box. This dialog box also lets you set up database options, external strategies, graphic options, and print settings.
What is a database connection?
A connection is a set of parameters that provides access to an RDBMS. These parameters include system information such as the data account, user identification, and the path to the database. Designer provides three types of connections: secured, shared, and personal.
Actually kinda!
But you need to use DBlinking or something to that nature.
http://docs.oracle.com/cd/B12037_01/server.101/b10759/statements_5005.htm
You can connect multiple source, like we have single universe with SAP HANA, Teradat and SAP BW. Check with IDT (BOXI 4.0) it has this feature.
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